Tadalafil and Sildenafil are both phosphodiesterase type 5 (PDE5) inhibitors used primarily for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). They work by increasing blood flow through vasodilation, enhancing erectile function and reducing vascular resistance in the lungs.
Tadalafil (Cialis, Adcirca)
Sildenafil (Viagra, Revatio)
Duration
Duration
Long-acting (up to 36 hours, often called the “weekend pill”)
Short Acting (4-6 hours)
Uses
Uses
-Erectile Dysfunction- Provides a more natural and spontaneous approach to sexual activity due to its prolonged duration.
-Erectile Dysfunction- Works quickly (30-60 minutes onset), making it ideal for planned sexual activity.
–Benign Prostatic Hyperplasia– Reduces urinary symptoms like frequent urination.
–Pulmonary Arterial Hypertension- Improves blood flow to reduce pulmonary pressure.
Take one capsule by mouth 30 minutes prior to activity.
7mg/200 IU daily use (Capsule Color: Light Blue/Maroon)
Take one capsule by mouth daily.
Sildenafil/Oxytocin
55mg/200 IU (Capsule Color: Light Blue)
10mg/200 IU (Capsule Color: Dark Blue)
Take one capsule by mouth 30 minutes prior to activity.
Sildenafil/Tadalafil/Oxytocin
55mg/22mg/200 IU (Capsule Color: Orange)
Take one capsule by mouth 30 minutes prior to activity.
What is Oxytocin?
Oxytocin is a neuropeptide hormone produced by the hypothalamus released primarily by the posterior pituitary gland. It plays a crucial role in social bonding, emotional connection, childbirth, and lactation. Often referred to as the “love hormone” or “cuddle hormone,” oxytocin is released during physical touch, sexual activity, and orgasms.
Oxytocin promotes blood flow to genital areas, contributing to increased arousal while also enhancing dopamine and serotonin levels to improve mood and sexual interest.
Oxytocin strengthens emotional connection between partners by fostering trust, attachment, and affection. This emotional closeness can enhance relationship satisfaction, indirectly improving sexual health.
Oxytocin may improve erectile dysfunction by increasing nitric oxide availability and promoting vasodilation. It may also complement PDE5 inhibitors (tadalafil/sildenafil) for men with mild erectile dysfunction.
Combining Tadalafil, Sildenafil, and Oxytocin Orally:
What is the Purpose and Benefits?
The combination of tadalafil, sildenafil, and oxytocin is designed to enhance sexual performance, arousal, and intimacy by targeting multiple physiological pathways involved in sexual function.
This combination helps:
Increase blood flow for stronger erections
Enhanced Libido & Arousal
Improve Orgasm Intensity & Pleasure
Reduced Anxiety & Stress for Better Performance
Better Emotional Connection & Intimacy
What is Clomiphene?
Clomiphene (also known by the brand name Clomid) is a selective estrogen receptormodulator (SERM) commonly used in reproductive medicine. It works by binding to estrogen receptors in the hypothalamus, effectively blocking estrogen’s negative feedback mechanism. This leads to an increase in gonadotropin-releasing hormone (GnRH) secretion, which stimulates the pituitary to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH)– both essential hormones for fertility.
Uses in Women
Clomiphene is most often used to treat ovulatory dysfunction in women who are struggling with infertility. Common conditions include
1. Polycystic Ovary Syndrome (PCOS)
2.Anovulation (lack of ovulation)
3. Irregular Menstrual Cycles
It induces ovulation by promoting the development and release of mature eggs, typically taken early in the menstrual cycle (e.g., days 3-7 or 5-9
Uses in Men
Though originally developed for women, Clomiphene is also used off-label in men for conditions related to hypogonadism and male infertility:
1. Low testosterone (secondary hypogonadism)
It increases LH and FSH production, stimulating the testes to produce more testosterone And sperm, while preserving fertilty (unlike exogenous testosterone therapy).
2. Oligospermia (low sperm count)
It can be an effective option for men wanting to boost testosterone without compromising sperm production.
What is Enclomiphene?
Enclomiphene is the isolated trans-isomer of clomiphene citrate, which is considered the more active and therapeutically beneficial component of the mixture found in standard clomiphene. It is a nonsteroidal selective estrogen receptor modulator (SERM) and works by blocking estrogen receptors in the hypothalamus, leading to increased production of gonadotropins (LH and FSH) from the pituitary gland. This boosts testosterone production and spermatogenesis in men and ovulation in women.
Uses in Women
Enclomiphene is being explored for similar indications as clomiphene in women, but is not widely studied. Potential applications include:
1. Ovulation induction in women with anovulation or irregular cycles
2. Polycystic Ovary Syndrome (PCOS)
Since enclomiphene lacks the zuclomiphene isomer (the longer-acting, potentially estrogenic part of clomiphene), it may offer fewer side effects and a more targeted effect for ovulation stimulation.
Uses in Men
Enclomiphene has gained significant attention in men’s health and hormone therapy, particularly for:
1. Secondary Hypogonadism (low testosterone due to hypothalamic or pituitary dysfunction)